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KMID : 0861020030180010099
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Korea Journal of Herbology
2003 Volume.18 No. 1 p.99 ~ p.108
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Effects of Radix Polygalae Extract on Sociopsychological Stress
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Abstract
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Objectives : The effects of Radix Polygalae extract were tested for the anti-sociopsychological stress action.
Methods : 100g of crude drug of Radix Polygalae was extracted with pure water and the total extractive was evaporated under reduced pressure to give 17.0g. ICR male mice(20±2g) were fed orally with the dose of 100mg/kg/day for five days. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days.
Results : Radix Polygalae extract administered group showed a significant decrease of serum corticosterone secretion compared with control group. Noradrenaline secretions in the dorsal cortex of brain showed no change. Lipid peroxidation and cytotoxicity of the liver of mice were tested by measuring malondialdehyde and serum level of aspartate amintransferase(ALT), and Radix Polygalae extract admistration decreased serum level of ALT. Serum level of malondialdehyde did not changed either.
Conclusion : Above results suggest that Radix Polygalae extract can effectively rid the sociopsychological stress.
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